The Impact of Tumor-associated Macrophages on Chemoresistance <i>via</i> Angiogenesis in Colorectal Cancer

Background/Aim: The tumor microenvironment plays an important role in progression. Tumor-associated macrophages (TAMs) have been reported to promote proliferation, invasion, metastasis, angiogenesis, and immunosuppression. Furthermore, angiogenesis has induce chemoresistance due the inefficient distribution of drugs cancer cells. However, impact TAMs on via colorectal (CRC) remains unclear. aim study was evaluate chemotherapeutic outcome CRC. Patients Methods: We enrolled 54 patients who underwent chemotherapy for unresectable metastatic CRC after resection primary tumor. evaluated density degree by immunohistochemistry then explored correlation between outcome. we assessed any that neovascularity. Results: high-TAMs group had a significantly worse progression-free survival (p=0.0006) poorer response rate (p=0.0274) than low-TAMs group. In addition, positive observed neovascularity (r=0.665, p=0.0004). Conclusion: were shown